Short CV

Research topics

Based on results of my phD thesis I am investiganting the epithelial immune response in the fruit flys intestine. Especially the interaction between the microbiome and the host is not fully understood yet. Beside the classical antimicrobial peptide response via NF-kB pathways (Toll & Imd), I am interested in the DUOX response mechanisms that not only effects invading pathogens but even also the own microbiome. I want to understand how the host-microbiome-homeostatis is staying in balance.

Furthermore I am working with the airway epithelium of Drosophila. I am investiganting different epithelial phenotypes in the fly that model lifestyle diseases like  Asthma, COPD & lung cancer and try to investigate the underlying cell signalling mechanism that may cause the typical disease-like phenotypes. One major aspect is to test the influence of human suceptibility genes in the fly model to further investigate targets for a better treatment of this diseases.

Publications

2021   Raacke M, Kerr A, Dörpinghaus M , Brehmer J , Wu Y , Lorenzen S ,Fink C , Jacobs T , Roeder T , Sellau J , Bachmann A ,NG Metwally, Bruchhaus I (2021)
Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
Cells 2021, 10(7), 1656; https://doi.org/10.3390/cells10071656

2021   Wagner C, Uliczka K, Bossen J, Niu X, Fink C, Thiedmann M, Knop M, Vock C, Abdelsadik A, Zissler UM, Isermann K, Garn H, Pieper M, Wegmann M, Koczulla AR, Vogelmeier CF, Schmidt-Weber CB, Fehrenbach H, König P, Silvermann N, Renz H, Pfefferle P. Heine H, Roeder T (2021)
Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
Cell reports, 35(1): 108956, doi: 10.1016/j.celrep.2021.108956

2021   Richert E, Papenkort J, Klettner A, Tode J, Koinzer S, Brinkmann R, Fink C, Roeder T, Lucius R, Roider J (2021)
Response of Retinal Pigment Epithelium (RPE)-Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)
Lasers in Surgery and Medicine, 53(3): 359-369, doi:10.1002/lsm.23288

2020   Bossen J, Uliczka K, Steen L, Neugebauer P, Mai M.M-Q, Fink C, Stracke F, Heine H and Roeder T
Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models.
ALTEX, doi: 10.14573/altex.1912131

2020   Niu X, Fink C, Kallsen K, Mincheva V, Franzenburg S, Prange R, Bossen J, Heine H, Roeder T 
Balanced JAK/STAT signaling is critical to maintain the functional and structural integrity of the Drosophila respiratory epithelium.
BioRxiv doi: https://doi.org/10.1101/2020.06.19.160929

2020   Li Y, Romey-Glüsing R, Tahan Zadeh T, von Frieling J, Hoffmann J, Huebbe P, Bruchhaus I, Rimbach G, Fink C, Roeder T 
Furbellow (brown algae) extract increases lifespan in Drosophila by interfering with TOR-signalling.
Nutrients, 12:1172, doi:10.3390/nu12041172

2019 Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM-Q, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T 
An EGFR-induced Drosophila lung tumor model identifies alternative combination treatments.
Mol Cancer Ther, accepted for publication

2018 Prange R*, Thiedmann M*, Bhandari A, Mishra N, Sinha A, Häsler R, Rosenstiel P, Uliczka K, Wagner C, Yldirim AÖ, Fink C, Roeder T 
A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expendient target for intervention
Aging, 10: 2122-2135 doi: 10.18632/aging.101536

2018 von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TC, Roeder T, Rosenstiel P, Sommer F 
Grow with the challenge - microbial effects on epithelial proliferation, carcinogenesis and cancer therapy
Frontiers in Microbiology, doi: 10.3389/fmicb.2018.02020

2018 Stephano F, Nolte S, Hoffmann J, El-Kholy S, von Frieling J, Bruchhaus I, Fink C, Roeder T 
Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson’s disease model.
Scientific Reports, 8(1):2372

2018   Romey-Glüsing R*, Li Y*, Hoffmann J, von Frieling J, Knop M, Pfefferkorn R, Bruchhaus I, Fink C, Roeder T​ 
Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila
FASEB J​, accepted for publication

2017   Fink C, von Frieling J, Knop M, Roeder T 
Drosophila Fecal Sampling
Bio-protocols, accepted for publication

2017   Li Y, Tiedemann L, von Frieling J, Nolte S, El-Kholy S, Stephano F,  Gelhaus C, Bruchhaus I, Fink C, Roeder T (2017)
The role of monoaminergic neurotransmission for metabolic control in the fruit fly Drosophila melanogaster
Frontiers in Systems Neuroscience 1: 50. DOI=10.3389/fnsys.2017.00060

2016  Li Y, Hoffmann J, Li Y, Stephano F, Bruchhaus I, Fink C, Roeder T. Octopamine controls starvation resistance, life span and metabolic traits in Drosophila. Scientific Reports, accepted for publication

2016  Fink C, Hoffmann J, Knop M, Li Y, Isermann K, Roeder T. Intestinal FoxO signaling is required to survive oral infection in Drosophila. Mucosal Immunol. advance online publication

2016  Fink C, Roeder T. How well do surrogate hosts serve as model systems for understanding pathogenicity. Advances in Environmental   Microbiology, Ed. CJ Hurst.

2015  El-Kholy S, Stephano F, Li Y, Bhandari A, Fink C, Roeder T. Expression analysis of octopamine and tyramine receptors in Drosophila. Cell &   Tiss Res 361(3):669-684

2015  Oldefest M, Düsterhoft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I. Secreted Frizzled‐related Protein 3 (sFRP3)‐  mediated suppression of Interleukin‐6   receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the   osteoarthritisassociated rare double variant of sFRP3. Biochem J 468(3):507-518.

2015  Li Y, Fink C, El-Kholy S, Roeder T. The octopamine receptor octß2R is essential for ovulation and fertilization in the fruit fly Drosophila melanogaster. Arch Insect   Biochemistry & Physiology 88:168-178.

2014  Fink C, Schukies S, von Frieling J, Roeder T. Molekulare Analyse aminerger Signalwege im ZNS der Taufliege. Biospektrum 06.2014: 636-639.

2014  Faisal MN, Hoffmann J, El-Kholy S, Kallsen K, Wagner C, Bruchhaus I, Fink C, Roeder T. Transcriptional regionalization of the fruit fly’s airway epithelium. PLoS one 9:   e102534.

2013  Fink C, Staubach F, Kuenzel S, Baines JF, Roeder T. Non-invasive analysis of microbiome dynamics in the fruit fly Drosophila melanogaster.  Appl Environ Microbiol. 79:6984-6988.

2013  Hoffmann J, Romey R, Fink C, Yong, L, Roeder T . Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and f  emale   Drosophila. Aging 5: 315-327.