Christine Fink
Postdoc
R.808
Phone:
+49 431 880-2578
Telefax:
+49 431 880-4197
cfink@zoologie.uni-kiel.de
Short CV
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Postdoc, Kiel University, Germany |
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PhD student, Kiel University, Germany |
| Thesis: "Die Architektur des intestinalen Immunsystems der Taufliege Drosophila melanogaster" | |
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Maternal leave |
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Diploma studies in Biology, Kiel University, Germany |
| Thesis: "Der Einfluss des Hungerns auf die Transkriptionsaktivität isolierter Organe der Taufliege Drosophila melanogaster" |
Research topics
Based on results of my phD thesis I am investiganting the epithelial immune response in the fruit flys intestine. Especially the interaction between the microbiome and the host is not fully understood yet. Beside the classical antimicrobial peptide response via NF-kB pathways (Toll & Imd), I am interested in the DUOX response mechanisms that not only effects invading pathogens but even also the own microbiome. I want to understand how the host-microbiome-homeostatis is staying in balance.
Furthermore I am working with the airway epithelium of Drosophila. I am investiganting different epithelial phenotypes in the fly that model lifestyle diseases like Asthma, COPD & lung cancer and try to investigate the underlying cell signalling mechanism that may cause the typical disease-like phenotypes. One major aspect is to test the influence of human suceptibility genes in the fly model to further investigate targets for a better treatment of this diseases.
Publications
2016 Li Y, Hoffmann J, Li Y, Stephano F, Bruchhaus I, Fink C, Roeder T. Octopamine controls starvation resistance, life span and metabolic traits in Drosophila. Scientific Reports, accepted for publication
2016 Fink C, Hoffmann J, Knop M, Li Y, Isermann K, Roeder T. Intestinal FoxO signaling is required to survive oral infection in Drosophila. Mucosal Immunol. advance online publication
2016 Fink C, Roeder T. How well do surrogate hosts serve as model systems for understanding pathogenicity. Advances in Environmental Microbiology, Ed. CJ Hurst.
2015 El-Kholy S, Stephano F, Li Y, Bhandari A, Fink C, Roeder T. Expression analysis of octopamine and tyramine receptors in Drosophila. Cell & Tiss Res 361(3):669-684
2015 Oldefest M, Düsterhoft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I. Secreted Frizzled‐related Protein 3 (sFRP3)‐ mediated suppression of Interleukin‐6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritisassociated rare double variant of sFRP3. Biochem J 468(3):507-518.
2015 Li Y, Fink C, El-Kholy S, Roeder T. The octopamine receptor octß2R is essential for ovulation and fertilization in the fruit fly Drosophila melanogaster. Arch Insect Biochemistry & Physiology 88:168-178.
2014 Fink C, Schukies S, von Frieling J, Roeder T. Molekulare Analyse aminerger Signalwege im ZNS der Taufliege. Biospektrum 06.2014: 636-639.
2014 Faisal MN, Hoffmann J, El-Kholy S, Kallsen K, Wagner C, Bruchhaus I, Fink C, Roeder T. Transcriptional regionalization of the fruit fly’s airway epithelium. PLoS one 9: e102534.
2013 Fink C, Staubach F, Kuenzel S, Baines JF, Roeder T. Non-invasive analysis of microbiome dynamics in the fruit fly Drosophila melanogaster. Appl Environ Microbiol. 79:6984-6988.
2013 Hoffmann J, Romey R, Fink C, Yong, L, Roeder T . Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and f emale Drosophila. Aging 5: 315-327.