Molecular Physiology

Jakob von Frieling

PhD student

Phone: +49 431 880-4019
Telefax: +49 431 880-4197

Short CV

  • since 2015
PhD student, Kiel University, Germany
  • 2012 - 2015
Master studies, Kiel University, Germany
  Thesis: " Dopamine receptors in the Drosophila nervous system: physiological and behavioral aspects"
  • 2008 - 2012      
Bachelor studies, University of Göttingen, Germany
  Thesis: "Regulation der Corpora allata von Locusta migratoria durch die Neuropeptide Proctocolin und FMRFamid"


Research experience      

  • 2012/04 - 2012/09
Lab intern, Kiel University, Germany
  Project thesis: "Einfluss des Drosophila EGF-Rezeptors auf die Wundheilung und die Akkumulation von Triglyceriden"


Research topic

I am interested in effects of malnutrition and caloric restriction on epithelia-microbe interactions in the intestinal tract of Drosophila melanogaster. In detail, I will elucidate the contribution of epithelial cell-type specific alterations of candidate gene expression levels for maintaining intestinal immune homeostasis during malnutrition and caloric restriction. Furthermore, I try to answer the question if and how the identified signaling events in the epithelium and the changed microbiota shape inflammatory-like responses at the intestinal barrier.


Jakob von Frieling, Christine Fink, Jacob Hamm, Kenneth Klischies, Michael Forster, Thomas Carl Bosch, Thomas Roeder, Philip Rosenstiel, Felix Sommer (2018)
Grow with the challenge - microbial effects on epithelial proliferation, carcinogenesis and cancer therapy
Frontiers in Microbiology, doi: 10.3389/fmicb.2018.02020

Stephano F, Nolte S, Hoffmann J, El-Kholy S, von Frieling J, Bruchhaus I, Fink C, Roeder T (2018)
Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson’s disease model.
Scientific Reports, 8(1):2372

Romey-Glüsing R*, Li Y*, Hoffmann J, von Frieling J, Knop M, Pfefferkorn R, Bruchhaus I, Fink C, Roeder T (2017)
Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila
FASEB J​, accepted for publication

Fink C, von Frieling J, Knop M, Roeder T (2017)
Drosophila Fecal Sampling
Bio-protocols, accepted for publication

Li Y, Tiedemann L, von Frieling J, Nolte S, El-Kholy S, Stephano F,  Gelhaus C, Bruchhaus I, Fink C, Roeder T (2017)
The role of monoaminergic neurotransmission for metabolic control in the fruit fly Drosophila melanogaster
Frontiers in Systems Neuroscience 1: 50. DOI=10.3389/fnsys.2017.00060

2014 Christine Fink, Stella Schukies, Jakob von Frieling, Thomas Roeder. Molekulare Analyse aminerger Signalwege im ZNS der Taufliege. BIOspektrum Volume 20, Issue 6: 636-639