Molecular Physiology

Dr. Jakob von Frieling


Phone: +49 431 880-4019
Telefax: +49 431 880-4197

Short CV

  • since 2015
PhD student, Kiel University, Germany
  • 2012 - 2015
Master studies, Kiel University, Germany
  Thesis: " Dopamine receptors in the Drosophila nervous system: physiological and behavioral aspects"
  • 2008 - 2012      
Bachelor studies, University of Göttingen, Germany
  Thesis: "Regulation der Corpora allata von Locusta migratoria durch die Neuropeptide Proctocolin und FMRFamid"


Research experience      

  • 2012/04 - 2012/09
Lab intern, Kiel University, Germany
  Project thesis: "Einfluss des Drosophila EGF-Rezeptors auf die Wundheilung und die Akkumulation von Triglyceriden"


Research topic

I am interested in effects of malnutrition and caloric restriction on epithelia-microbe interactions in the intestinal tract of Drosophila melanogaster. In detail, I will elucidate the contribution of epithelial cell-type specific alterations of candidate gene expression levels for maintaining intestinal immune homeostasis during malnutrition and caloric restriction. Furthermore, I try to answer the question if and how the identified signaling events in the epithelium and the changed microbiota shape inflammatory-like responses at the intestinal barrier.


von Frieling J, Faisal NM, Sporn F, Pefferkorn R, Nolte SS, Sommer F, Rosenstiel P, Roeder T (2020)
A high fat diet induces a microbiota dependent increase in stem cell activity in the Drosophila intestine.
PLOS Genetics, 16(5):e1008789, doi:10.1371/journal.pgen.1008789

Li Y, Romey-Glüsing R, Tahan Zadeh T, von Frieling J, Hoffmann J, Huebbe P, Bruchhaus I, Rimbach G, Fink C, Roeder T (2020)
Furbellow (brown algae) extract increases lifespan in Drosophila by interfering with TOR-signalling.
Nutrients, 12:1172, doi:10.3390/nu12041172

von Frieling J, Roeder T (2020)
Factors that affect the translation of dietary restriction into a longer life.
IUBMB Life, 72(5): 814-824, doi:

Rausch P, Rühlemann M, Hermes B, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel-Humeida U, (...), Reusch TBH, Roeder T, Schmitz RA. Schulenburg H, Soluch R, Sommer F, Stuckenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019)
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.
Microbiome, 7:133, doi:

von Frieling J, Fink C, Hamm J, Klischies K,Forster M, Bosch TC, Roeder T, Rosenstiel P, Sommer F (2018)
Grow with the challenge - microbial effects on epithelial proliferation, carcinogenesis and cancer therapy
Frontiers in Microbiology, doi: 10.3389/fmicb.2018.02020

Stephano F, Nolte S, Hoffmann J, El-Kholy S, von Frieling J, Bruchhaus I, Fink C, Roeder T (2018)
Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson’s disease model.
Scientific Reports, 8(1):2372

Romey-Glüsing R*, Li Y*, Hoffmann J, von Frieling J, Knop M, Pfefferkorn R, Bruchhaus I, Fink C, Roeder T (2017)
Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila
FASEB J​, 32: 1992-2002,. doi: 10.1096/fj.201700934R

Fink C, von Frieling J, Knop M, Roeder T (2017)
Drosophila Fecal Sampling
Bio-protocols, 7(18): e2547. DOI: 10.21769/BioProtoc.2547

Li Y, Tiedemann L, von Frieling J, Nolte S, El-Kholy S, Stephano F,  Gelhaus C, Bruchhaus I, Fink C, Roeder T (2017)
The role of monoaminergic neurotransmission for metabolic control in the fruit fly Drosophila melanogaster
Frontiers in Systems Neuroscience 1: 50. DOI=10.3389/fnsys.2017.00060

Fink C, Schukies S, von Frieling J, Roeder R (2014)
Molekulare Analyse aminerger Signalwege im ZNS der Taufliege.
BIOspektrum Volume 20, Issue 6: 636-639