Molecular Physiology

Dr. Judith Bossen

Postdoc

R. 812
Phone: +49 431 880-2578
Telefax: +49 431 880-4197
jbossen@zoologie.uni-kiel.de

Short CV

  • 2014 - 2017

PhD student, Kiel University, Germany

  • 2011 - 2014      
Master studies, Kiel University, Germany
  Thesis: "Physiologische Rolle der Acyloxyacylhydrolase in Dictyostelium discoideum"
  • 2008 - 2011
Bachelor studies, Kiel University, Germany
  Thesis: "Analyse der Lysozym-Synthese bei Dictyostelium discoideum in der Abhängigkeit von der Gegenwart von Bakterien"

 

   
   
   
   

 

Research topic

I am working on the development and establishment of a lung cancer model in Drosophila. The aim is to understand the molecular and genetic basis of tumor formation and progression. Overexpression of cancer-associated genes (e.g. EGFR, Ras, MAPK) in the tracheal epithelium can induce cancer-like phenotypes like epithelial meta- and hyperplasia. I am investigating this phenotypes by microscopic analysis for differences on a cellular level (quantification of epithelial thickness, cell and nucleus size and number, cell connections and cell shape…) and by other methods (IHC, qPCR) to investigate the tumor formation on a translational and transcriptional level.

Publications


Bossen J, Uliczka K, Steen L, Neugebauer P, Mai M.M-Q, Fink C, Stracke F, Heine H and Roeder T (2020)
Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models.
ALTEX, doi: 10.14573/altex.1912131

Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM-Q, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T (2019)
An EGFR-induced Drosophila lung tumor model identifies alternative combination treatments.
Mol Cancer Ther, accepted for publication

Uliczka K, Bossen J, Pfefferkorn R, Heine H and Roeder T (2015)
Etablierung eines Drosophila-Lungenkarzinom-Modells.
Pneumologie, 69-A7