Molecular Physiology

Judith Bossen

Postdoc

R. 812
Phone: +49 431 880-2578
Telefax: +49 431 880-4197
jbossen@zoologie.uni-kiel.de

Short CV

  • 2014 - 2017

PhD student, Kiel University, Germany
  • 2011 - 2014      
 Master studies, Kiel University, Germany
  Thesis: "Physiologische Rolle der Acyloxyacylhydrolase in Dictyostelium discoideum"
  • 2008 - 2011
 Bachelor studies, Kiel University, Germany
  Thesis: "Analyse der Lysozym-Synthese bei Dictyostelium discoideum in der Abhängigkeit von der Gegenwart von Bakterien"

 

   
   
   
   

 

Research topic

I am working on the development and establishment of a lung cancer model in Drosophila. The aim is to understand the molecular and genetic basis of tumor formation and progression. Overexpression of cancer-associated genes (e.g. EGFR, Ras, MAPK) in the tracheal epithelium can induce cancer-like phenotypes like epithelial meta- and hyperplasia. I am investigating this phenotypes by microscopic analysis for differences on a cellular level (quantification of epithelial thickness, cell and nucleus size and number, cell connections and cell shape…) and by other methods (IHC, qPCR) to investigate the tumor formation on a translational and transcriptional level.

Publications


Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM-Q, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T (2019)
An EGFR-induced Drosophila lung tumor model identifies alternative combination treatments.
Mol Cancer Ther, accepted for publication

Uliczka K, Bossen J, Pfefferkorn R, Heine H, Roeder T. Etablierung eines Drosophila-Lungenkarzinom-Modells. Pneumologie. 2015;69-A7