Molecular Physiology

Ruben Prange

Master student

R.808
Phone: +49 431 880-4019
Telefax: +49 431 880-4197
rprange@zoologie.uni-kiel.de

Short CV

  • since 2013
Master studies, Kiel University, Germany
  • 2010 - 2013
Bachelor studies, University of Hamburg, Germany
 
Thesis: "Establishment of a measuring method for a FRET-based biosensor on the Operetta high content imaging system"

 

Research experience      

 
  • 2015
Lab intern, Perkin Elmer in Hamburg, Germany
  Project thesis: "Comparative measurements concerning speed and quality of different high content imaging system"

 

Research topic

My research interest lies in the activation of COPD (Chronic Obstructive Pulmonary Disease) dependent signalling pathways in Drosophila. To apply Drosophila to cigarette smoke I am using a vacuum based method. After smoke exposure, the trachea of the flies must be dissected to further investigate potential COPD dependent activation motifs.

My mainly used methods to study the trachea of different fly strains are qRT-PCR and light/fluorescence microscopy. Moreover I am investigating the potential impact of myokines on the lifespan of smoke exposed flies. Myokines are secreted by a contracting muscle and are supposed to enhance the lifespan of other cells and therefore lead to longevity of a whole organism.

Due to the increasing mortality rate of this disease, the development of potential approaches to prevent or to milden the burden of COPD may become more and more important.

Publications

2016 Hans-Joachim Müller and Daniel Ruben Prange. PCR - Polymerase Kettenreaktion. Spinger-Verlag Berlin Heidelberg

2016 Foitzik A., Prange R., Böttcher K., Schreiner A. Opera Phenix High Conten Screening System Technical Performance: Speed. Perkin Elmer Technical Note