Molecular Physiology

Jakob von Frieling

PhD student

Phone: +49 431 880-4019
Telefax: +49 431 880-4197
jfrieling@zoologie.uni-kiel.de

Short CV

  • since 2015
PhD student, Kiel University, Germany
  • 2012 - 2015
Master studies, Kiel University, Germany
  Thesis: " Dopamine receptors in the Drosophila nervous system: physiological and behavioral aspects"
  • 2008 - 2012      
Bachelor studies, University of Göttingen, Germany
  Thesis: "Regulation der Corpora allata von Locusta migratoria durch die Neuropeptide Proctocolin und FMRFamid"

 

Research experience      

  
  • 2012/04 - 2012/09
Lab intern, Kiel University, Germany
  Project thesis: "Einfluss des Drosophila EGF-Rezeptors auf die Wundheilung und die Akkumulation von Triglyceriden"

 

Research topic

I am interested in effects of malnutrition and caloric restriction on epithelia-microbe interactions in the intestinal tract of Drosophila melanogaster. In detail, I will elucidate the contribution of epithelial cell-type specific alterations of candidate gene (NF-kB (Relish, Dorsal), Duox and Upd3) expression levels for maintaining intestinal immune homeostasis during malnutrition and caloric restriction. Furthermore, I try to answer the question if and how the identified signaling events in the epithelium and the changed microbiota shape inflammatory-like responses and carcinogenesis at the intestinal barrier. Additionally, I am interested  in the hormonal and aminergic regulation of the gut.

Publications

Romey-Glüsing R*, Li Y*, Hoffmann J, von Frieling J, Knop M, Pfefferkorn R, Bruchhaus I, Fink C, Roeder T (2017)
Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila
FASEB J​, accepted for publication

Fink C, von Frieling J, Knop M, Roeder T (2017)
Drosophila Fecal Sampling
Bio-protocols, accepted for publication

Li Y, Tiedemann L, von Frieling J, Nolte S, El-Kholy S, Stephano F,  Gelhaus C, Bruchhaus I, Fink C, Roeder T (2017)
The role of monoaminergic neurotransmission for metabolic control in the fruit fly Drosophila melanogaster
Frontiers in Systems Neuroscience 1: 50. DOI=10.3389/fnsys.2017.00060

2014 Christine Fink, Stella Schukies, Jakob von Frieling, Thomas Roeder. Molekulare Analyse aminerger Signalwege im ZNS der Taufliege. BIOspektrum Volume 20, Issue 6: 636-639