Molecular Physiology

Ruben Prange

PhD

R.808
Phone: +49 431 880-4019
Telefax: +49 431 880-4197
rprange@zoologie.uni-kiel.de

Short CV

  • since 2016
PhD student, Kiel University, Germany
  • 2013 - 2016
Master studies, Kiel University, Germany
  • 2010 - 2013
Bachelor studies, University of Hamburg, Germany
 
Thesis: "Establishment of a measuring method for a FRET-based biosensor on the Operetta high content imaging system"

 

Research experience      

 
  • 2015
Lab intern, Perkin Elmer in Hamburg, Germany
  Project thesis: "Comparative measurements concerning speed and quality of different high content imaging system"

 

Research topic

My research interest lies in the activation of COPD (Chronic Obstructive Pulmonary Disease) dependent signalling pathways in Drosophila. Due to the increasing mortality rate of this disease, the development of potential approaches to prevent or to milden the burden of COPD becomes more and more important.

Transcriptomic analyses reveal the Nrf2 and JAK/STAT signalling pathway being involved in the airway epithelial response to cigarette smoke. Interference with the Nrf2 pathway leads to an increased antioxidant response and is beneficial for survival. Hence, modulation of certain COPD related pathways might display a potential treatment approach for managing the burden of this disease.

Publications

2018 Prange R., Thiedmann M., Bhandari A., Mishra N., Sinha A., Häsler R., Rosenstiel P., Uliczka K., Wagner C., Yildirim AÖ., Fink C., Roeder T. A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention. Aging (Albany NY), 2018 AUg 27;10(8):2122-2135. doi: 10.18632/aging.101536

2016 Hans-Joachim Müller and Daniel Ruben Prange. PCR - Polymerase Kettenreaktion. Spinger-Verlag Berlin Heidelberg

2016 Foitzik A., Prange R., Böttcher K., Schreiner A. Opera Phenix High Conten Screening System Technical Performance: Speed. Perkin Elmer Technical Note